Elevated TYROBP expression predicts poor prognosis and high tumor immune infiltration in patients with low-grade glioma.

ABSTRACT:

Background

Tyrosine protein tyrosine kinase binding protein (TYROBP) binds non-covalently to activated receptors on the surface of various immune cells, and mediates signal transduction and cellular activation. It is dysregulated in various malignancies, although little is known regarding its role in low-grade glioma. The aim of this study is to explore the clinicopathological significance, prognostic value and immune signature of TYROBP expression in low-grade glioma (LGG).

Methods

The differentially expressed genes (DEGs) between glioma samples and normal tissues were identified from two GEO microarray datasets using the limma package. The DEGs overlapping across both datasets were functionally annotated by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KE

SUBMITTER: Lu J 

PROVIDER: S-EPMC8220692 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature