Molecular docking, chemo-informatic properties, alpha-amylase, and lipase inhibition studies of benzodioxol derivatives.

ABSTRACT: Currently, available therapies for diabetes could not achieve normal sugar values in a high percentage of treated patients. In this research project, a series of 17 benzodioxole derivatives were evaluated as antidiabetic agents; that belong to three different groups were evaluated against lipase and alpha-amylase (α-amylase) enzymes. The results showed that 14 compounds have potent inhibitory activities against α-amylase with IC₅₀ values below 10 µg/ml. Among these compounds, 4f was the most potent compound with an IC₅₀ value of 1.11 µg/ml compared to the anti-glycemic agent acarbose (IC₅₀ 6.47 µg/ml). On the contrary, these compounds showed weak or negligible activities against lipase enzyme. However, compound 6a showed the best inhibitory anti-lipase acti

SUBMITTER: Hawash M 

PROVIDER: S-EPMC8220737 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature