Role of hippocampal location and radiation dose in glioblastoma patients with hippocampal atrophy.

ABSTRACT:

Background

The hippocampus is a critical organ for irradiation. Thus, we explored changes in hippocampal volume according to the dose delivered and the location relative to the glioblastoma.

Methods

All patients were treated for glioblastoma with surgery, concomitant radiotherapy and temozolomide, and adjuvant temozolomide. Hippocampi were retrospectively delineated on three MRIs, performed at baseline, at the time of relapse, and on the last MRI available at the end of follow-up. A total of 98, 96, and 82 hippocampi were measured in the 49 patients included in the study, respectively. The patients were stratified into three subgroups according to the dose delivered to 40% of the hippocampus. In the group 1 (n = 6), the hippocampal D_40% was < 7.4 Gy, in the group

SUBMITTER: Le Fevre C 

PROVIDER: S-EPMC8220779 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature