Neuropsychiatric Effects on Decision-Making in Early Alzheimer Disease.

ABSTRACT:

Background

Neuropsychiatric symptoms can impact decision-making in patients with Alzheimer disease (AD).

Methods

Using a simple decision-making task, a variant of the ultimatum game (UG) modified to control feelings of unfairness, this study investigated rejection responses among responders to unfair offers. The UG was administered to 11 patients with AD, 10 comparably demented patients with behavioral variant frontotemporal dementia (bvFTD), and 9 healthy controls (HC). The results were further compared with differences on the caregiver Neuropsychiatric Inventory (NPI).

Results

Overall, patients with AD significantly rejected more total offers than did the patients with bvFTD and the HC (P < .01). On the NPI, the only domain that was significantly worse among

SUBMITTER: Yerstein O 

PROVIDER: S-EPMC8220792 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature