Protein arginine methyltransferase 1 regulates cell proliferation and differentiation in adult mouse adult intestine.

ABSTRACT:

Background

Adult stem cells play an essential role in adult organ physiology and tissue repair and regeneration. While much has been learnt about the property and function of various adult stem cells, the mechanisms of their development remain poorly understood in mammals. Earlier studies suggest that the formation of adult mouse intestinal stem cells takes place during the first few weeks after birth, the postembryonic period when plasma thyroid hormone (T3) levels are high. Furthermore, deficiency in T3 signaling leads to defects in adult mouse intestine, including reduced cell proliferation in the intestinal crypts, where stem cells reside. Our earlier studies have shown that protein arginine methyltransferase 1 (PRMT1), a T3 receptor coactivator, is highly expressed during inte

SUBMITTER: Xue L 

PROVIDER: S-EPMC8220849 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature