Hormonal contraceptive use and depressive symptoms: systematic review and network meta-analysis of randomised trials.

ABSTRACT:

Background

Observational studies suggest that hormonal contraceptive use may increase depressive symptoms in women, but it is unclear whether the effect is causal.

Aims

To quantitatively examine the evidence from randomised clinical trials for the link between hormonal contraceptive use and depressive symptoms.

Method

We performed a systematic review and network meta-analysis of randomised clinical trials comparing women randomised to any form of a hormonal contraceptive with women randomised to any other form of a (non-)hormonal contraceptive or placebo. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Web of Science, PsycINFO, EMCare and EMBASE, from inception to 1 May 2020. Certainty of the evidence was assessed with the Grading of

SUBMITTER: de Wit AE 

PROVIDER: S-EPMC8220855 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature