Comparison of explicit and mean-field models of cytoskeletal filaments with crosslinking motors.

ABSTRACT: In cells, cytoskeletal filament networks are responsible for cell movement, growth, and division. Filaments in the cytoskeleton are driven and organized by crosslinking molecular motors. In reconstituted cytoskeletal systems, motor activity is responsible for far-from-equilibrium phenomena such as active stress, self-organized flow, and spontaneous nematic defect generation. How microscopic interactions between motors and filaments lead to larger-scale dynamics remains incompletely understood. To build from motor-filament interactions to predict bulk behavior of cytoskeletal systems, more computationally efficient techniques for modeling motor-filament interactions are needed. Here, we derive a coarse-graining hierarchy of explicit and continuum models for crosslinking motors that bind to

SUBMITTER: Lamson AR 

PROVIDER: S-EPMC8220871 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature