Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia.

ABSTRACT:

Background

The efficacy and safety of tofacitinib, a Janus kinase inhibitor, in patients who are hospitalized with coronavirus disease 2019 (Covid-19) pneumonia are unclear.

Methods

We randomly assigned, in a 1:1 ratio, hospitalized adults with Covid-19 pneumonia to receive either tofacitinib at a dose of 10 mg or placebo twice daily for up to 14 days or until hospital discharge. The primary outcome was the occurrence of death or respiratory failure through day 28 as assessed with the use of an eight-level ordinal scale (with scores ranging from 1 to 8 and higher scores indicating a worse condition). All-cause mortality and safety were also assessed.

Results

A total of 289 patients underwent randomization at 15 sites in Brazil. Overall, 89.3% of the patients received

SUBMITTER: Guimaraes PO 

PROVIDER: S-EPMC8220898 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature