Ontology highlight
ABSTRACT:
SUBMITTER: Provance OK
PROVIDER: S-EPMC8221017 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Provance Olivia K OK Geanes Eric S ES Lui Asona J AJ Roy Anuradha A Holloran Sean M SM Gunewardena Sumedha S Hagan Christy R CR Weir Scott S Lewis-Wambi Joan J
Cancer letters 20210520
Overexpression of interferon induced transmembrane protein-1 (IFITM1) enhances tumor progression in multiple cancers, but its role in triple-negative breast cancer (TNBC) is unknown. Here, we explore the functional significance and regulation of IFITM1 in TNBC and strategies to target its expression. Immunohistochemistry staining of a tissue microarray demonstrates that IFITM1 is overexpressed in TNBC samples which is confirmed by TCGA analysis. Targeting IFITM1 by siRNA or CRISPR/Cas9 in TNBC c ...[more]