Antibody Conjugate Assembly on Ultrasound-Confined Microcarrier Particles.

ABSTRACT: Bioconjugates are important next-generation drugs and imaging agents. Assembly of these increasingly complex constructs requires precise control over processing conditions, which is a challenge for conventional manual synthesis. This inadequacy has motivated the pursuit of new approaches for efficient, controlled modification of high-molecular-weight biologics such as proteins, carbohydrates, and nucleic acids. We report a novel, hands-free, semiautomated platform for synthetic manipulation of biomolecules using acoustically responsive microparticles as three-dimensional reaction substrates. The microfluidic reactor incorporates a longitudinal acoustic trap that controls the chemical reactions within a localized acoustic field. Forces generated by this field immobilize the microscale subst

SUBMITTER: Binkley MM 

PROVIDER: S-EPMC8221231 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature