Genomic Characterization of mcr-1.1-Producing Escherichia coli Recovered From Human Infections in Sao Paulo, Brazil.

ABSTRACT: Polymyxins are one of most important antibiotics available for multidrug-resistant Gram-negative infections. Diverse chromosomal resistance mechanisms have been described, but the polymyxin resistance phenotype is not yet completely understood. The objective of this study was to characterize colistin resistant mcr-1-producing strains isolated from human infections over one year in a hospital setting (Hospital das Clínicas, São Paulo, Brazil). We isolated 490 colistin-resistant Gram-negative rods, of which eight were mcr-1.1-positive Escherichia coli, the only species with this result, indicating a low incidence of the mcr-1 production mechanism among colistin-resistant isolates. All mcr-1.1 positive isolates showed similarly low MICs for colistin and were

SUBMITTER: Girardello R 

PROVIDER: S-EPMC8221240 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature