Sulfonium-based liposome-encapsulated antibiotics deliver a synergistic antibacterial activity.

ABSTRACT: The devastating antibacterial infections, coupled with their antibiotic resistance abilities, emphasize the need for effective antibacterial therapeutics. In this prospect, liposomal delivery systems have been employed in improving the efficacy of the antibacterial agents. The liposome-based antibiotics enhance the therapeutic potential of the new or existing antibiotics and reduce their adverse effects. The current study describes the development of sulfonium-based antibacterial lipids that demonstrate the delivery of existing antibiotics. The presence of cationic sulfonium moieties and inherent membrane targeting abilities of the lipids could help reduce the antibiotic resistance abilities of the bacteria and deliver the antibiotics to remove the infectious pathogens electively. The tran

SUBMITTER: Patel A 

PROVIDER: S-EPMC8221259 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature