Myeloid-specific SIRT1 deletion exacerbates airway inflammatory response in a mouse model of allergic asthma.

ABSTRACT: Sirtuin 1 (SIRT1) is a class III histone deacetylase that exerts an anti-inflammatory effect in airway diseases. Activated macrophages play an important role in asthma. However, the roles of SIRT1 on allergic airway inflammation in macrophages remain largely unexplored. In this study, we aimed to determine the roles of SIRT1 on allergic airway inflammation in macrophages. The effect of myeloid-specific SIRT1 deletion (Sirt1^fl/fl-LysMcre) on airway inflammation was assessed by using in vivo models of asthma following allergen exposure and in vitro culture of primary bone marrow-derived macrophages (BMDMs) exposed to house dust mite (HDM). We observed that Sirt1^fl/fl-LysMcre mice substantially enhanced airway inflammation and mu

SUBMITTER: Lai T 

PROVIDER: S-EPMC8221322 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature