Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines.

ABSTRACT:

Objective

To demonstrate differences in cardiovascular structure and function between diabetic and non-diabetic older adults. To investigate associations between acyl-carnitines and cardiovascular function as indexed by imaging measurements.

Methods

A community-based cohort of older adults without cardiovascular disease underwent current cardiovascular imaging and metabolomics acyl-carnitines profiling based on current and archived sera obtained fifteen years prior to examination.

Results

A total of 933 participants (women 56%, n=521) with a mean age 63±13 years were studied. Old diabetics compared to old non-diabetics had lower myocardial relaxation (0.8±0.2 vs 0.9±0.3, p=0.0039); lower left atrial conduit strain (12±4.3 vs 14±4.1, p=0.045), lower left atrial conduit

SUBMITTER: Gao F 

PROVIDER: S-EPMC8221346 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature