Prevalence of proliferating CD8⁺ cells in normal lymphatic tissues, inflammation and cancer.

ABSTRACT: CD8⁺ cytotoxic T-lymphocytes are essential components of the anti-tumor immunity. To better understand the expansion of CD8⁺ T-cells we used multiplex fluorescence immunohistochemistry to study Ki67⁺CD8⁺ cells in normal lymphoid tissues, selected inflammatory diseases and cancers in 41 large sections/ microenvironment tissue microarrays (TMAs) as well as 765 samples in a conventional TMA format. The evaluation of more than 20 different compartments of normal lymphoid tissues revealed that the percentage of proliferating (ki67⁺) CD8⁺ cells did commonly not exceed 3%. In inflammations, the percentage of Ki67⁺CD8⁺ cells was more variable and higher compared to normal tissues. In cancers, the percentage of

SUBMITTER: Blessin NC 

PROVIDER: S-EPMC8221353 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature