Preferential tumor localization in relation to ¹⁸F-FDOPA uptake for lower-grade gliomas.

ABSTRACT:

Purpose

Although tumor localization and 3,4-dihydroxy-6-¹⁸F-fluoro-L-phenylalanine (FDOPA) uptake may have an association, preferential tumor localization in relation to FDOPA uptake is yet to be investigated in lower-grade gliomas (LGGs). This study aimed to identify differences in the frequency of tumor localization between FDOPA hypometabolic and hypermetabolic LGGs using a probabilistic radiographic atlas.

Methods

Fifty-one patients with newly diagnosed LGG (WHO grade II, 29; III, 22; isocitrate dehydrogenase wild-type, 21; mutant 1p19q non-codeleted,16; mutant codeleted, 14) who underwent FDOPA positron emission tomography (PET) were retrospectively selected. Semiautomated tumor segmentation on FLAIR was performed. Patients with LGGs were separated into two g

SUBMITTER: Tatekawa H 

PROVIDER: S-EPMC8221401 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature