Genetic Predictors of Early-Onset Spinal Intervertebral Disc Degeneration: Part One of Two.

ABSTRACT: Intervertebral disc (IVD) degeneration is a progressive and painful pathology that can root from mechanical, biochemical, and environmental stressors. However, recent advancements in biogenetics have now found a predominating genetic influence. Nevertheless, despite these advancements, the pathophysiology of IVD degeneration remains poorly understood. In the first of our two-part series, we will characterize some of the most recent and best-studied genes in the context of intervertebral disc degeneration. We will attempt to formulate the first contemporary gene guide that characterizes the genetic profile of IVD degeneration. The genes of interest include aggrecan (ACAN), matrix metalloproteinase 2 (MMP2), vitamin D receptor (VDR), interleukin 1 alpha (IL1A), and those encoded for collagen

SUBMITTER: Fiani B 

PROVIDER: S-EPMC8221406 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature