DNA methylation variant, B-vitamins intake and longitudinal change in body mass index.

ABSTRACT:

Background

Growing evidence has implicated DNA methylation (DNAm) in the regulation of body adiposity; a recent epigenome-wide association study (EWAS) identified a genetic variant determining DNAm at the SREBF1 gene that affected body mass index (BMI).

Objective

In the present study, we tested interactions between DNAm variant rs752579 and methylation metabolism-related B-vitamins (folate, vitamin B₂, vitamin B₆, and vitamin B₁₂) on longitudinal change in BMI in the Women's Health Initiative Memory Study (WHIMS).

Design

A total of 5687 white women aged 65-79 from WHIMS with genotyping data on SNP rs752579 were included in the analysis. B-vitamins intakes were estimated by a self-report semi-quantitative food frequency questionnaire. B

SUBMITTER: Li X 

PROVIDER: S-EPMC8221450 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature