Delayed diapedesis of CD8 T cells contributes to long-term pathology after ischemic stroke in male mice.

ABSTRACT:

Objective

Stroke is a debilitating disorder with significant annual mortality and morbidity rates worldwide. Immune cells are recruited to the injured brain within hours after stroke onset and can exhibit either protective or detrimental effects on recovery. However, immune cells, including CD8 T cells, persist in the injured brain for weeks, suggesting a longer-term role for the adaptive immune system during functional recovery. The aim of this study was to determine if the delayed secondary diapedesis of CD8 T cells into the ischemic brain negatively impacts functional recovery after transient ischemic stroke in male mice.

Results

Mice exhibited an increased number of leukocytes in the ipsilesional hemispheres at 14 days (3-fold; p < 0.001) and 30 days (2.2-fold; p = 0.02)

SUBMITTER: Selvaraj UM 

PROVIDER: S-EPMC8221572 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature