Genetic Predictors of Early-Onset Spinal Intervertebral Disc Degeneration: Part Two of Two.

ABSTRACT: Understanding genetic indicators is a fundamental aspect to characterizing the pathophysiology of chronic diseases such as intervertebral disc degeneration (IVDD). In our previous spinal genetics review, we characterized some more common genetic influencers in the context of IVDD. In this second part of our two-part comprehensive spinal genetics review, we characterize the more infrequently studied genes that have pathophysiological relevance. In doing so, we aim to expand upon the current gene-library for IVDD. The genes of interest include: asporin, cartilage intermediate layer protein, insulin-like growth factor 1 receptor, matrix metallopeptidase 9, and thrombospondin 2. Findings show that these genetic indicators have trends and polymorphisms that ma

SUBMITTER: Fiani B 

PROVIDER: S-EPMC8221650 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature