A Five-Gene Prognostic Nomogram Predicting Disease-Free Survival of Differentiated Thyroid Cancer.

ABSTRACT:

Background

Differentiated thyroid cancer (DTC) is the most common type of thyroid tumor with a high recurrence rate. Here, we developed a nomogram to effectively predict postoperative disease-free survival (DFS) in DTC patients.

Methods

The mRNA expressions and clinical data of DTC patients were downloaded from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. Seventy percent of patients were randomly selected as the training dataset, and thirty percent of patients were classified into the testing dataset. Multivariate Cox regression analysis was adopted to establish a nomogram to predict 1-year, 3-year, and 5-year DFS rate of DTC patients.

Results

A five-gene signature comprised of TENM1, FN1, APOD, F12, and BTNL8 genes was established to

SUBMITTER: Ruchong P 

PROVIDER: S-EPMC8221860 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature