Dataset Information
BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial.
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ABSTRACT:
SUBMITTER: Prentice S
PROVIDER: S-EPMC8222005 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial.
The Lancet. Infectious diseases 20210217 7
<h4>Background</h4>Trials done in infants with low birthweight in west Africa suggest that BCG vaccination reduces all-cause mortality in the neonatal period, probably because of heterologous protection against non-tuberculous infections. This study investigated whether BCG alters all-cause infectious disease morbidity in healthy infants in a different high-mortality setting, and explored whether the changes are mediated via trained innate immunity.<h4>Methods</h4>This was an investigator-blind, ...[more]