Abnormal phase discontinuity of alpha- and theta-frequency oscillations in schizophrenia.

ABSTRACT:

Background

Schizophrenia patients have abnormal electroencephalographic (EEG) power over multiple frequency bands, even at rest, though the primary neural generators and spatiotemporal dynamics of these abnormalities are largely unknown. Disturbances in the precise synchronization of oscillations within and across cortical sources may underlie abnormal resting-state EEG activity in schizophrenia patients.

Methods

A novel assessment method was applied to identify the independent contributing sources of resting-state EEG and assess the phase discontinuity in schizophrenia patients (N = 148) and healthy subjects (N = 143).

Results

A network of 11 primary contributing sources of scalp EEG was identified in both groups. Schizophrenia patients showed abnormal elevations of

SUBMITTER: Koshiyama D 

PROVIDER: S-EPMC8222093 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature