Respiratory exacerbations are associated with muscle loss in current and former smokers.

ABSTRACT:

Objectives

Muscle wasting is a recognised extra-pulmonary complication in chronic obstructive pulmonary disease and has been associated with increased risk of death. Acute respiratory exacerbations are associated with reduction of muscle function, but there is a paucity of data on their long-term effect. This study explores the relationship between acute respiratory exacerbations and long-term muscle loss using serial measurements of CT derived pectoralis muscle area (PMA).

Design and setting

Participants were included from two prospective, longitudinal, observational, multicentre cohorts of ever-smokers with at least 10 pack-year history.

Participants

The primary analysis included 1332 (of 2501) participants from Evaluation of COPD Longitudinally to Identify Predicti

SUBMITTER: Mason SE 

PROVIDER: S-EPMC8222105 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature