Immune Checkpoint-Bioengineered Beta Cell Vaccine Reverses Early-Onset Type 1 Diabetes.
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ABSTRACT:
SUBMITTER: Au KM
PROVIDER: S-EPMC8222180 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
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Immune Checkpoint-Bioengineered Beta Cell Vaccine Reverses Early-Onset Type 1 Diabetes.
Au Kin Man KM Medik Yusra Y Ke Qi Q Tisch Roland R Wang Andrew Z AZ
Advanced materials (Deerfield Beach, Fla.) 20210508 25
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease that results from autoreactive T cells destroying insulin-producing pancreatic beta (β) cells. The development of T1DM is associated with the deficiency of co-inhibitory immune checkpoint ligands (e.g., PD-L1, CD86, and Gal-9) in β cells. Here, a new translational approach based on metabolic glycoengineering and bioorthogonal click chemistry, which bioengineers β cells with co-inhibitory immune checkpoint molecules that induce antig ...[more]
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