Natural genetic variation drives microbiome selection in the Caenorhabditis elegans gut.

ABSTRACT: Host genetic landscapes can shape microbiome assembly in the animal gut by contributing to the establishment of distinct physiological environments. However, the genetic determinants contributing to the stability and variation of these microbiome types remain largely undefined. Here, we use the free-living nematode Caenorhabditis elegans to identify natural genetic variation among wild strains of C. elegans that drives assembly of distinct microbiomes. To achieve this, we first established a diverse model microbiome that represents the strain-level phylogenetic diversity naturally encountered by C. elegans in the wild. Using this community, we show that C. elegans utilizes immune, xenobiotic, and metabolic signaling pathways to favor the assembly of different microbiome types. Variations i

SUBMITTER: Zhang F 

PROVIDER: S-EPMC8222194 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature