Transcriptional and epigenetic landscape of Ca²⁺-signaling genes in hepatocellular carcinoma.

ABSTRACT: Calcium (Ca²⁺) signaling has a major role in regulating a wide range of cellular mechanisms, including gene expression, proliferation, metabolism, cell death, muscle contraction, among others. Recent evidence suggests that ~ 1600 genes are related to the Ca²⁺ signaling. Some of these genes' expression is altered in several pathological conditions, including different cancer types, and epigenetic mechanisms are involved. However, their expression and regulation in hepatocellular carcinoma (HCC) and the liver are barely known. Here, we aimed to explore the expression of genes involved in the Ca²⁺-signaling in HCC, liver regeneration, and hepatocyte differentiation, and whether their expression is regulated by epigenetic mechanisms such as DNA methylation and

SUBMITTER: Hernandez-Oliveras A 

PROVIDER: S-EPMC8222487 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature