The Effects of rs405509 on APOEε4 Non-carriers in Non-demented Aging.

ABSTRACT:

Background

There is evidence that the T allele of rs405509 located in the apolipoprotein E (APOE) promotor region is a risk factor for Alzheimer's disease (AD). However, the effect of the T/T allele on brain function in non-demented aging is still unclear.

Methods

We analyzed the effects of the rs405509 T/T allele on cognitive performances using multiple neuropsychological tests and local brain function using resting-state functional magnetic resonance imaging (rs-fMRI).

Results

Significant differences were found between T/T carriers and G allele carriers on general cognitive status, memory, and attention (p < 0.05). Rs-fMRI analyses demonstrated decreased amplitude of low frequency fluctuation (ALFF) in the right middle frontal gyrus, decreased percent

SUBMITTER: Wu D 

PROVIDER: S-EPMC8222619 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature