Voxel-Based Morphometry of Cerebellar Lobules in Essential Tremor.

ABSTRACT:

Background

The extent of neurodegeneration underlying essential tremor (ET) remains a matter of debate. Despite various extents of cerebellar atrophy on structural magnetic resonance imaging (MRI), previous studies have shown substantial heterogeneity and included a limited number of patients. Novel automated pipelines allow detailed segmentation of cerebellar lobules based on structural MRI.

Objective

To compare the volumes of cerebellar lobules in ET patients with those in healthy controls (HCs) using an automated segmentation pipeline.

Methods

Structural MRI scans of ET patients eligible for deep brain stimulation (n = 55) and of age-matched and gender-matched HCs (n = 55, from the IXI database) were segmented using the automated CEREbellum Segmentati

SUBMITTER: Agren R 

PROVIDER: S-EPMC8222624 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature