LRRC3B Polymorphisms Contributed to Breast Cancer Susceptibility in Chinese Han Population.

ABSTRACT:

Purpose

LRRC3B gene, as a tumor suppressor gene was involved in the development and progress of breast cancer (BC). However, the effect of LRRC3B polymorphisms on BC has rarely been reported. In the study, we aimed to evaluate the relation between LRRC3B variants and BC risk.

Methods

Among 563 BC patients and 552 healthy controls, ten single-nucleotide polymorphisms (SNPs) in LRRC3B were genotyped by Agena MassARRAY. Odds ratios (ORs) and 95% confidence interval (CI) were calculated using logistic regression model.

Results

Our study demonstrated that rs1907168 polymorphism (heterozygous: OR = 0.71, p = 0.017) was related to the reduced risk of BC in the overall. In stratified analyses by age, rs1907168 was associated with the decreas

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8222685 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature