Interleukin-35 Suppresses Interleukin-9-Secreting CD4⁺ T Cell Activity in Patients With Hepatitis B-Related Hepatocellular Carcinoma.

ABSTRACT: Chronic hepatitis B virus (HBV) infection induces dysfunction of immune response and chronic liver damage. However, the mechanisms that account for HBV-related hepatocellular carcinoma (HCC) are poorly understood. The aim of present study was to investigate the modulatory role of interleukin (IL)-35, an immunosuppressive cytokine, to IL-9-secreting T cells in hepatitis B-related HCC. Twenty-two HBV-related HCC patients, twenty-seven chronic hepatitis B (CHB) patients, and eleven controls were enrolled. Serum IL-35 and IL-9 concentration was measured by ELISA. Peripheral and liver-infiltrating non-specific and HBV-specific Th9 and Tc9 cells were assessed by flow cytometry. The regulatory activity of IL-35 to peripheral and liver-infiltrating Th9 cells was assessed in co-culture system betwe

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC8222719 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature