Secretory products of the corpus luteum and preeclampsia.

ABSTRACT:

Background

Despite significant advances in our understanding of the pathophysiology of preeclampsia (PE), there are still many unknowns and controversies in the field. Women undergoing frozen-thawed embryo transfer (FET) to a hormonally prepared endometrium have been found to have an unexpected increased risk of PE compared to women who receive embryos in a natural FET cycle. The differences in risk have been hypothesized to be related to the absence or presence of a functioning corpus luteum (CL).

Objective and rationale

To evaluate the literature on secretory products of the CL that could be essential for a healthy pregnancy and could reduce the risk of PE in the setting of FET.

Search methods

For this review, pertinent studies were searched in PubMed/Medline (updat

SUBMITTER: Pereira MM 

PROVIDER: S-EPMC8222764 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature