Investigating the ACE2 polymorphisms in COVID-19 susceptibility: An in silico analysis.

ABSTRACT:

Background

Novel coronavirus (SARS-CoV-2) became an epidemic disease and lead to a pneumonia outbreak first in December 2019 in Wuhan, China. The symptoms related to coronavirus disease-19 (COVID-19) were different ranging from mild to severe lung injury and multi-organ failure symptoms, eventually leading to death, especially in older patients with other co-morbidities. The receptor of this virus in the human cell is angiotensin-converting enzyme 2 (ACE2).

Methods

In this paper, we aimed to perform an in silico analysis of the frequently studied variants of the ACE2 gene and determine the effects of the variants in mRNA secondary structure and binding affinity of cellular factors. Fourteen single-nucleotide polymorphisms were selected based on previous studies and investiga

SUBMITTER: Pouladi N 

PROVIDER: S-EPMC8222831 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature