Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication*.
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ABSTRACT:
SUBMITTER: Melidis L
PROVIDER: S-EPMC8222931 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication*.
Melidis Lazaros L Hill Harriet J HJ Coltman Nicholas J NJ Davies Scott P SP Winczura Kinga K Chauhan Tasha T Craig James S JS Garai Aditya A Hooper Catherine A J CAJ Egan Ross T RT McKeating Jane A JA Hodges Nikolas J NJ Stamataki Zania Z Grzechnik Pawel P Hannon Michael J MJ
Angewandte Chemie (International ed. in English) 20210709 33
The untranslated regions (UTRs) of viral genomes contain a variety of conserved yet dynamic structures crucial for viral replication, providing drug targets for the development of broad spectrum anti-virals. We combine in vitro RNA analysis with molecular dynamics simulations to build the first 3D models of the structure and dynamics of key regions of the 5' UTR of the SARS-CoV-2 genome. Furthermore, we determine the binding of metallo-supramolecular helicates (cylinders) to this RNA structure. ...[more]
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