Function and Evolution of Nuclear Receptors in Environmental-Dependent Postembryonic Development.

ABSTRACT: Nuclear receptors (NRs) fulfill key roles in the coordination of postembryonal developmental transitions in animal species. They control the metamorphosis and sexual maturation in virtually all animals and by that the two main environmental-dependent developmental decision points. Sexual maturation and metamorphosis are controlled by steroid receptors and thyroid receptors, respectively in vertebrates, while both processes are orchestrated by the ecdysone receptor (EcR) in insects. The regulation of these processes depends on environmental factors like nutrition, temperature, or photoperiods and by that NRs form evolutionary conserved mediators of phenotypic plasticity. While the mechanism of action for metamorphosis and sexual maturation are well studied in model organisms, the evolution

SUBMITTER: Taubenheim J 

PROVIDER: S-EPMC8222990 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature