Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster.
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ABSTRACT:
SUBMITTER: Meyer H
PROVIDER: S-EPMC8223033 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
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Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in <i>Drosophila melanogaster</i>.
Meyer Heiko H Buhr Annika A Callaerts Patrick P Schiemann Ronja R Wolfner Mariana F MF Marygold Steven J SJ
microPublication biology 20210623
The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space. Impaired neprilysin activity is associated with numerous human diseases. Here, we present a comprehensive list and classification of M13 family members in <i>Drosophila melanogaster</i>. Seven <i>Neprilysin</i> (<i>Nep</i>) genes encode active peptidases, while 21 <i>Neprilysin-like</i> (<i>Nepl</i>) gene ...[more]
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