Altered Relationship Between Heart Rate Variability and fMRI-Based Functional Connectivity in People With Epilepsy.

ABSTRACT: Background: Disruptions in central autonomic processes in people with epilepsy have been studied through evaluation of heart rate variability (HRV). Decreased HRV appears in epilepsy compared to healthy controls, suggesting a shift in autonomic balance toward sympathetic dominance; recent studies have associated HRV changes with seizure severity and outcome of interventions. However, the processes underlying these autonomic changes remain unclear. We examined the nature of these changes by assessing alterations in whole-brain functional connectivity, and relating those alterations to HRV. Methods: We examined regional brain activity and functional organization in 28 drug-resistant epilepsy patients and 16 healthy controls using resting-state functional magnetic resonance imag

SUBMITTER: Kassinopoulos M 

PROVIDER: S-EPMC8223068 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature