Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness.

ABSTRACT:

Importance

Schizophrenia is a complex heritable disorder associated with many genetic variants, each with a small effect. While cortical differences between patients with schizophrenia and healthy controls are consistently reported, the underlying molecular mechanisms remain elusive.

Objective

To investigate the extent of shared genetic architecture between schizophrenia and brain cortical surface area (SA) and thickness (TH) and to identify shared genomic loci.

Design, setting, and participants

Independent genome-wide association study data on schizophrenia (Psychiatric Genomics Consortium and CLOZUK: n = 105 318) and SA and TH (UK Biobank: n = 33 735) were obtained. The extent of polygenic overlap was investigated using MiXeR. The specific shared genomic loci were i

SUBMITTER: Cheng W 

PROVIDER: S-EPMC8223140 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature