Completeness and Consistency in Structural Domain Classifications.

ABSTRACT: Domain classifications are a useful resource for computational analysis of the protein structure, but elements of their composition are often opaque to potential users. We perform a comparative analysis of our classification ECOD against the SCOPe, SCOP2, and CATH domain classifications with respect to their constituent domain boundaries and hierarchal organization. The coverage of these domain classifications with respect to ECOD and to the PDB was assessed by structure and by sequence. We also conducted domain pair analysis to determine broad differences in hierarchy between domains shared by ECOD and other classifications. Finally, we present domains from the major facilitator superfamily (MFS) of transporter proteins and provide evidence that supports their split into domains and for m

SUBMITTER: Schaeffer RD 

PROVIDER: S-EPMC8223206 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature