Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study.

ABSTRACT:

Background

Pain and fatigue are persistent problems in people with rheumatoid arthritis. Central sensitisation (CS) may contribute to pain and fatigue, even when treatment has controlled inflammatory disease. This study aims to validate a self-report 8-item questionnaire, the Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA) questionnaire, developed to measure central pain mechanisms in RA, and to predict patient outcomes and response to treatment. A secondary objective is to explore mechanisms linking CS, pain and fatigue in people with RA.

Methods/design

This is a prospective observational cohort study recruiting 250 adults with active RA in secondary care. The CAP-RA questionnaire, demographic data, medical history, and patient reported outcome measures (PROMs) of

SUBMITTER: Ifesemen OS 

PROVIDER: S-EPMC8223274 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature