Network-based analysis of virulence factors for uncovering Aeromonas veronii pathogenesis.

ABSTRACT:

Background

Aeromonas veronii is a bacterial pathogen in aquaculture, which produces virulence factors to enable it colonize and evade host immune defense. Given that experimental verification of virulence factors is time-consuming and laborious, few virulence factors have been characterized. Moreover, most studies have only focused on single virulence factors, resulting in biased interpretation of the pathogenesis of A. veronii.

Results

In this study, a PPI network at genome-wide scale for A. veronii was first constructed followed by prediction and mapping of virulence factors on the network. When topological characteristics were analyzed, the virulence factors had higher degree and betweenness centrality than other proteins in the network. In particular, the virulence facto

SUBMITTER: Li H 

PROVIDER: S-EPMC8223281 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature