Event-related potentials to rare visual targets and negative symptom severity in a transdiagnostic psychiatric sample.

ABSTRACT:

Objectives

Negative psychiatric symptoms are often resistant to treatments, regardless of the disorder in which they appear. One model for a cause of negative symptoms is impairment in higher-order cognition. The current study examined how particular bottom-up and top-down mechanisms of selective attention relate to severity of negative symptoms across a transdiagnostic psychiatric sample.

Methods

The sample consisted of 130 participants: 25 schizophrenia-spectrum disorders, 26 bipolar disorders, 18 unipolar depression, and 61 nonpsychiatric controls. The relationships between attentional event-related potentials following rare visual targets (i.e., N1, N2b, P2a, and P3b) and severity of the negative symptom domains of anhedonia, avolition, and blunted affect were evaluated

SUBMITTER: Salgari GC 

PROVIDER: S-EPMC8223322 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature