Zoledronic acid and teriparatide have a complementary therapeutic effect on aseptic loosening in a rabbit model.

ABSTRACT:

Background

Revisions are mainly caused by wear debris-induced aseptic loosening. How to effectively suppress debris-induced periprosthetic osteolysis has become an urgent problem. Both zoledronic acid and teriparatide can increase the bone mass around prostheses and increase the stability of prostheses. A hypothesis was proposed: the combination of the two drugs may have a better treatment effect than the use of either drug alone.

Methods

We created a rabbit model to study the effect and mechanism of the combination of zoledronic acid and teriparatide in the treatment of aseptic loosening. Thirty-two adult male New Zealand white rabbits were selected and treated with TKA surgery, and a titanium rod prosthesis coated evenly with micrometre-sized titanium debris was implanted

SUBMITTER: Wang P 

PROVIDER: S-EPMC8223324 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature