Clinical manifestations of hereditary angioedema and a systematic review of treatment options.

ABSTRACT:

Objective

This study systematically reviews the existing literature on the management of hereditary angioedema (HAE) and provides an update on the clinical presentation and specific therapies.

Methods

A literature search of PubMed and Embase databases was conducted from start of the database to February 2021. Inclusion criteria included relevant systematic reviews, randomized control clinical trials, prospective and retrospective cohort studies, and outcomes research published in English and available in full-text. Out of 310 candidate articles, a total of 55 articles were included in our study.

Results

The most common genetic form of HAE in up to 85% of cases is caused by low levels of C1 esterase inhibitor (C1-INH) protein, leading to a bradykinin-mediated increase

SUBMITTER: Rosi-Schumacher M 

PROVIDER: S-EPMC8223449 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature