Myofiber strain in healthy humans using DENSE and cDTI.

ABSTRACT:

Purpose

Myofiber strain, E_ff , is a mechanistically relevant metric of cardiac cell shortening and is expected to be spatially uniform in healthy populations, making it a prime candidate for the evaluation of local cardiomyocyte contractility. In this study, a new, efficient pipeline was proposed to combine microstructural cDTI and functional DENSE data in order to estimate E_ff in vivo.

Methods

Thirty healthy volunteers were scanned with three long-axis (LA) and three short-axis (SA) DENSE slices using 2D displacement encoding and one SA slice of cDTI. The total acquisition time was 11 minutes ± 3 minutes across volunteers. The pipeline first generates 3D SA displacements from all DENSE slices which are then combined with cDTI data to generate a cine of

SUBMITTER: Moulin K 

PROVIDER: S-EPMC8223515 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature