DRB1-environment interactions in multiple sclerosis etiology: results from two Swedish case-control studies.

ABSTRACT:

Objective

We aimed to investigate the influence of environmental risk factors for multiple sclerosis (MS) in different genetic contexts, and study if interactions between environmental factors and human leucocyte antigen (HLA) genes differ in magnitude according to heterozygocity and homozygocity for HLA-DRB1*15:01.

Methods

Using population-based case-control studies (6985 cases, 6569 controls), subjects with different genotypes and smoking, EBNA-1 status and adolescent Body Mass status, were compared regarding MS risk, by calculating OR with 95% CI employing logistic regression. The interaction between different genotypes and each environmental factor was evaluated on the additive scale.

Results

The effect of each DRB1*15:01 allele on MS risk was additi

SUBMITTER: Hedstrom AK 

PROVIDER: S-EPMC8223646 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature