Genetic architectures of proximal and distal colorectal cancer are partly distinct.

ABSTRACT:

Objective

An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined.

Design

To identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48 214 CRC cases

SUBMITTER: Huyghe JR 

PROVIDER: S-EPMC8223655 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature