Alternative Complement Pathway Is Activated and Associated with Galactose-Deficient IgA₁ Antibody in IgA Nephropathy Patients.

ABSTRACT:

Background

Galactose-deficient IgA₁ (Gd-IgA₁) and alternative complement pathway activation are considered to be involved in the pathogenesis of IgA nephropathy (IgAN). Nevertheless, the relationships between alternative pathway activation and disease activity or Gd-IgA₁ level remains unclear.

Methods

Ninety-eight biopsy-diagnosed IgAN, twenty-five primary focal segmental sclerosis (FSGS) patients and forty-two healthy individuals were recruited in this study. Among them, fifty IgAN patients received immunosuppression. Follow-up blood samples at 1 and 3~6 months after immunosuppression were collected. Plasma levels of complement C5a, factor Ba and Gd-IgA₁ were measured and analyzed. Immunostaining for complement was performed in tw

SUBMITTER: Chiu YL 

PROVIDER: S-EPMC8223746 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature