Cerebral Edema in Traumatic Brain Injury: a Historical Framework for Current Therapy.

ABSTRACT:

Purpose of review

The purposes of this narrative review are to (1) summarize a contemporary view of cerebral edema pathophysiology, (2) present a synopsis of current management strategies in the context of their historical roots (many of which date back multiple centuries), and (3) discuss contributions of key molecular pathways to overlapping edema endophenotypes. This may facilitate identification of important therapeutic targets.

Recent findings

Cerebral edema and resultant intracranial hypertension are major contributors to morbidity and mortality following traumatic brain injury. Although Starling forces are physical drivers of edema based on differences in intravascular vs extracellular hydrostatic and oncotic pressures, the molecular pathophysiology underlying cerebra

SUBMITTER: Zusman BE 

PROVIDER: S-EPMC8223756 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature