Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.

ABSTRACT:

Background

The high morbidity and mortality of colorectal cancer (CRC) have posed great threats to human health. Circular RNA (CircRNA) and microRNA (miRNA), acting as competing endogenous RNAs (ceRNAs), have been found to play vital roles in carcinogenesis. However, the biological function of ceRNAs in CRC pathogenesis and prognosis remains largely unexplored.

Aim

To identify the CRC-specific circRNA-miRNA-mRNA regulatory network and uncover the subnetwork associated with its prognosis.

Methods

CircRNAs, miRNAs and mRNAs differentially expressed (DE) in CRC tissues were selected by expression file analysis in the Gene Expression Omnibus (GEO) database, and the downstream target molecules of circRNAs and miRNAs were predicted. Then, the intersection of differentially

SUBMITTER: Yin TF 

PROVIDER: S-EPMC8223824 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature